[1]吴承芳 黎 瑩 陈保霖 朱永苹.消化性溃疡患者根除HP 后发生 胃食管反流病的研究[J].大众科技,2019,21(02):65-67.
 Study of Gastroesophageal Reflux Disease after HP Eradicationin Patients with Peptic Ulcer[J].Popular Science & Technology,2019,21(02):65-67.
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消化性溃疡患者根除HP 后发生 胃食管反流病的研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年02
页码:
65-67
栏目:
医药与卫生
出版日期:
2019-02-20

文章信息/Info

Title:
Study of Gastroesophageal Reflux Disease after HP Eradicationin Patients with Peptic Ulcer
作者:
吴承芳1 黎 瑩1 陈保霖1 朱永苹2
(1.广西中医药大学,广西 南宁 530001;2.广西中医药大学附属瑞康医院,广西 南宁 530010)
关键词:
消化性溃疡幽门螺杆菌胃食管反流病
Keywords:
peptic ulcer helicobacter pylori gastroesophageal reflux disease
文献标志码:
A
摘要:
目的:观察消化性溃疡患者根除幽门螺杆菌(HP)后发生胃食管反流病的情况,探讨HP 与胃食管反流病(GERD)的关系。方法:将60 例HP 阳性消化性溃疡患者随机分为观察组和对照组,各30 例,观察两组患者总体疗效,GerdQ 评分,HP 根除情况及两组患者治疗前、后及停药3 个月胃食管反流发生情况。结果:对照组总有效率明显低于观察组(P<0.05);对照组GerdQ 评分明显低于观察组(t=2.243,P<0.05);观察组HP 根除率高于对照组(χ2=7.2,P<0.05);治疗后,在消化性溃疡患者发生胃食管反流病方面,观察组与对照组差异无统计学意义(χ2=0.3,P>0.05);停药3 月后,观察组有3 例消化性溃疡患者发生胃食管反流病,对照组有5 例,差异无统计学意义(χ2=0.577,P>0.05)。结论:消化性溃疡患者经根除HP 后效果显著,HP 与胃食管反流病的发生可能不存在相关性。
Abstract:
Objective: To observe the occurrence of gastroesophageal reflux disease (GERD) after HP eradication in patients with peptic ulcer. Methods: 60 patients with helicobacter pylori (HP) positive peptic ulcer were randomly divided into the observation group and the control group, 30 patients each group. The overall efficacy, GerdQ score, HP eradication, and the occurrence of gastroesophageal reflux before, after and after treatment for 3 months were observed. Results: The total effective rate of the control group was significantly lower than that of the observation group (P<0.05). The GerdQ score of the control group was significantly lower than that of the observation group (t=2.243, P<0.05). The eradication rate of HP in the observation group was higher than that in the control group (χ2=7.2, P<0.05). After treatment, there was no statistically significant difference between the observation group and the control group in the occurrence of gastroesophageal reflux disease in patients with peptic ulcer (χ2=0.3, P>0.05). Three patients with peptic ulcer developed gastroesophageal reflux disease in the observation group and 5 patients in the control group after 3 months of drug withdrawal, with no statistically significant difference (χ2=0.577, P>0.05). Conclusion: The effect of HP eradication on peptic ulcer was significant, and there was no correlation with the occurrence of gastroesophageal reflux.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2018-12-06 【基金项目】国家自然科学基金课题(81560758);广西研究生教育创新计划资助项目(YJSP201744)。 【作者简介】吴承芳(1990-),女(壮族),广西来宾人,广西中医药大学在读硕士研究生,研究方向为消化系统疾病的中西医结合诊治。 【通信作者】朱永苹(1972-),女,广西合浦人,广西中医药大学附属瑞康医院主任医师,副教授,硕士研究生导师,研究方向为消化系统疾病的中西医结合诊治。
更新日期/Last Update: 2019-04-19